[PDF] Galectin-1 and Galectin-9 Concentration in Maternal Serum: Implications in Pregnancies Complicated with Preterm Prelabor Rupture of Membranes | Semantic Scholar (2024)

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Compared to healthy pregnant women, serum galectin-9 concentrations taken before delivery were positively correlated with BMI and parameters related to the amount of adipose tissue assessed in the early postpartum period, and there was a correlation between serum galECTin- 9 concentrations take before and after delivery.

The galectin-9 influence on phenotype transformation and Tim-3 expression of NK cells isolated from peripheral blood of healthy non-pregnant fertile women and NK cell subpopulation distributions in vitro culture are studied.

This paper comprehensively reviews the indications for amniocentesis and chorionic villus sampling and examines various methods of genomic, infectious, and biochemical analysis, with a particular emphasis on the achievements of the last decade.

Lower UC gal-1 levels, when mothers were older, and increasedUC gal-3 levels in cases of gestational diabetes, possibly reflect angiogenic activity in intrauterine growth restricted, large and appropriate for gestational age (AGA) pregnancies.

Chorioamnionitis is associated with an increased galectin-1 mRNA expression and strong immunoreactivity of the chorioamniotic membranes; thus, galectIn-1 may be involved in the regulation of the inflammatory responses to chorioamionitis.

The results suggest that gal-1 plays a key role in pregnancy maternal immune regulation by modulating HLA-G expression on trophoblast cells, and could serve as a predictive factor for pregnancy success in early human gestation.

Identification of early changes in maternal immune and angiogenic factors during pregnancy may be a tool to improve patient counseling on pregnancy loss risk and future interventions to reduce miscarriage in a subset of women.

It is suggested that Gal-9/TIM-3 pathway could play an important role in the immune regulation during pregnancy and the altered Galectin-9 and TIM-3 expression could result an enhanced systemic inflammatory response including the activation of Th1 lymphocytes in preeclampsia.

Th1/Th2 imbalance, sTim-3 and Galectin-9 expression increase are found in the patients with URSA, ant this might be involved in the regulation of immunity in pregnancy.

Encoded transcripts and proteins indicated active tissue remodeling independent of labor status and an association with inflammatory processes during labor, suggesting a probable association with the underlying pathology.

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